H. pylori, Hormones and Your Gut Health
Hello, I am Julie Donaldson and I am a clinical nutritionist with functional medicine training. I specialize in restoring balance in complex, chronic and acute health conditions. I welcome you to peruse other articles that may be of interest to you in your health investigation!
“Julie has been a great support in my healing journey bringing to light things that have been in the shadows and revealing deeper sources of healing to me. Julie encouraged me to think critically and intuitively about all that I consume and to challenge ideologies that might not stand true for me any more.”
- KM, Canada
What is H. pylori?
Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative bacteria found in the mouth and stomach capable of utilizing oxygen & respiring it to carbon dioxide. It was identified in 1982 by Australian scientists Barry Marshall and Robin Warren, who made the link between H. pylori and gastric ulcers, a condition not previously associated with GI microbial disease. The bacteria is also associated with high oxidative stress, stomach cancer, autoimmune and non-autoimmune thyroid diseases and breakdown of body tissues.
H pylori is a potent, acid-tolerant cytotoxic bacteria with detrimental effects on gut health, including risks of leaky gut, gas, pain, nausea and stomach cancer. Other holistic health concerns such as hormone balance, adrenal and liver functions and neurotransmission may also be involved. Destruction of the inner layers of the blood vessels via inflammatory processes with infection is known to contribute to heart disease, especially with chronic infections such as that of H.pylori.
H pylori is present in normal amounts in the oral & gut mucosa, but becomes dangerous when present in abnormal amounts. The risk of infection increases via oral contact with others who are infected.
H. pylori is the most common chronic bacterial pathogen in humans. Statistics show that more than 50% of the world’s population is infected with this potent bacteria. (In the U.S., infection rates jump to 61% after the holidays! Rates of infection increase with age, and the prevalence of infection rises 1% with every year of life. Therefore, we can expect that approximately 80% of 80 year-olds are infected with H. pylori. With the incidence of H. pylori infections increasing with age, it follows that hypochlorhydria (low hydrochloric acid) also increases with age, given our understanding that the bacteria prefers low acid conditions.
Up to 85% of people infected with H. pylori never experience symptoms or complications. Acute infection may present with abdominal pain, nausea, and/or irritable bowel symptoms. Bloating, belching, vomiting, and sometimes black stools develop with chronic infection. Bleeding in the upper GI tract causes black stool, and a chronic bleed can contribute to anemia with weakness and fatigue. When a person is symptomatic, the pain of H. pylori is usually felt when the stomach is empty, between meals, and especially early in the morning.
Individuals infected with H. pylori have a 10-20% lifetime risk of developing peptic ulcers and a 1-2% risk of acquiring stomach cancer. There have also been risks identified with the development of colorectal polyps and colorectal cancer. This is one of the reasons why having access to gut health support through the convenience of holistic telehealth services is so valuable.
The evasive colonizing techniques of H. pylori
To avoid the acidic environment of the stomach, H. pylori uses its flagella to burrow into the mucus lining of the stomach. By doing this, it can reach the epithelial cells underneath, where the environment is less acidic. H. pylori is able to sense the pH gradient in the mucus and move into friendlier territory for its survival. This is called chemotaxis. This also allows the bacteria to be excluded from being swept away into the lumen of the stomach by the natural actions of mucus and lymph. In addition to using chemotaxis to avoid areas of low pH, H. pylori also neutralizes the acid in its environment by producing large amounts of urease, which breaks down the urea present in the stomach to produce the elements of carbon dioxide and ammonia.
Many people lacking gut health support will experience high-ammonia symptoms with H. pylori, such as fatigue, lack of concentration, muscle weakness, irritability, pain, nausea, etc.
Numerous survival mechanisms of H. pylori which make it quite difficult to detect in many conventional stool tests. With our holistic telehealth services at True Nature, we use a PCR assay stool test which detects the presence of the bacteria by its genetic coding rather than a required presence in the stool sample itself. This is key to proper identification, as many people who are infected with H. pylori go undiagnosed due to a “negative” result on a stool sample. Successful identification is the first step in a gut health support process that will truly eradicate this problematic pathogen.
H. pylori and food
The fermentation of malabsorbed carbohydrates in the gut produces hydrogen gas. Hydrogen gas is the preferred energy source for H. pylori. Elevated hydrogen gases are also associated with other nasty bugs such as Salmonella, E. coli and Campylobacter jejuni. Sugars (including fructose), starches, and some fibrous carbohydrates contribute to this fermentation and gas production.
Other important considerations are food sensitivities and leaky gut syndrome. A mucosal barrier that is damaged by autoimmune reactions to foods is a very vulnerable place for pathogens to enter and set up a colony. This is why gut health support is so important - the stomach is designed to be a closed system, ready and able to attack pathogens as they enter, with sufficient healthy bacteria as well as stomach acid. When this environment is opened in leaky gut conditions, illness risks increase dramatically.
H. pylori and virulence factor
While further study is needed to confirm risk factors and complications of H. pylori expression, there are indications that certain genetic virulence factors may contribute to more severe inflammatory responses and more pronounced pathological changes in some individuals.
When a person has H. pylori, the strain diversity increases over time. The presence of any virulence factor increases the potential for symptoms and disease. The average person with HP has 2.5 different strains. Each strain will have its own set (or not) of virulence factors. A bacteria like H. pylori can double in amount every 1-2 hours. So over a short period of time, levels can increase dramatically.
With lower amounts of the bacteria in the digestive tract, the dilution occurring as they pass through the stomach and 2700 grams of fecal matter can create difficulty with detecting both the bacteria and their virulence factors. The PCR assay test used at True Nature resolves this challenge through the detection of their genetic codes.
H. pylori, hormones and neurotransmission
Another area of great interest surrounding gut health support and H. pylori is the advancement in understanding of negative influences of steroidal hormones on the infection. A scholarly paper published in 2011 by Hirofumi Shimomura, following extensive research, showed that pregnenolone, dehydroepiandrosterone (DEA), epiandrosterone (EA) and estrone (E1) are all absorbed into the lipid membrane of H. pylori. As steroids, they have the capacity to strengthen and reinforce the membrane barrier and increase its resistance to treatment/eradication.
The reinforced barrier creates resistance of H. pylori to phosphatidylcholines, a group of phospholipids that includes linoleic and/or arachidonic acid. These are polyunsaturated fatty acids (PUFAs) that provide antibacterial actions which are fatal to the typically steroid-free H. pylori membrane. Despite its low abundance in the cell membrane, phosphatidyl serine plays key roles in various functions such as the coagulation cascade, clearance of apoptotic (dying) cells, and recruitment of signaling molecules. Phosphatidyl serine also localizes in endocytic organelles which are responsible for “cell drinking” and “cell eating”, two forms of moving nutrients into cells by the creation of vacuoles. Essentially, this part of the membrane engulfs material and then sorts it - utilizing or creating waste of it.
Also important to note is that phospholipid molecules such as phosphatidyl serine have both polar and non-polar lipid regions, and because of this, can have difficulty finding stability to begin with. The phosphate portion of the molecule seeks water, while the lipid portion seeks oil. Between the innate instability and the blockage of phosphatidyl serine by steroidal hormones, these endocytic cellular nutrition functions become impaired.
Unlike DEA, EA and pregnenolone, estradiol (E2), androstenedione, and progesterone are harmful for the survival of H. pylori. Progesterone exhibits the most effective antibacterial action against H pylori. Progesterone inhibits the absorption of free-cholesterol by H. pylori and conversely, high levels of free-cholesterol inhibit the antibacterial actions of progesterone. These two hormones appear to bind to identical sites on the bacteria and therefore can obstruct each other’s effects.
One study indicates that licorice root may positively impact the treatment of H. pylori. Licorice is an adaptogenic herb which supports adrenal function and hormone balance. This is more proof that hormones and our guts are intimately connected. Further information indicates that there are likely effects on the brain-gut axis by H. pylori. These may arise from a direct neurotoxic effect, activation of inflammatory processes in nerves and micronutrient deficiency. Intermediate effects of chronic H. pylori infection on brain-gut axis function have been clinically observed as:
changes in eating patterns
cognitive and memory dysfunction
increased vulnerability to stress, anxiety and depressive behaviors.
What all of this means for a person infected with H. pylori is that the infection does not exist in isolation of the body’s complex metabolic functions. It is not a simple scenario of a gut infection that is easily eradicated with conventional therapies - you will need quality gut health support. The infection burrows deep into the lining of the gut where antibiotics may not reach it, and is impacted by adrenal and liver health/balance. Other factors such as poor cholesterol synthesis and hormone toxicity can alter the natural balances and strategies employed by a healthy body in attacking an infection such as H. pylori.
What are the connections between H pylori, vitamin D and the thyroid?
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What are the connections between H pylori, vitamin D and the thyroid? 〰️
H. pylori and vitamin D
Vitamin D is key to resolving gut infections inclusive of H. pylori. It boosts the immune system's ability to fight off pathogens and strengthens the intestinal barrier, which keeps harmful substances out.
Vitamin D deficiency can weaken this barrier, disrupt the balance of healthy gut bacteria , and increase susceptibility to infections and inflammatory conditions.
As we’ve discussed, both vitamin D deficiency and lack of VDR (vitamin D receptor) activation can allow excess oxidative stress which is known to be problematic in H. pylori infections. Oxidative stress is known to catabolize (break down) body tissues, and H. pylori infections are linked with body catabolism also via the depletion of glutathione, one of the body’s most important and self-producing antioxidants. Antioxidants are a necessary part of maintaining redox balance and limiting oxidative stress. When catabolism occurs, muscle wasting, weight loss and low cholesterol levels may occur.
H. pylori, autoimmune & non-autoimmune thyroid conditions
H. pylori infections are associated with autoimmune thyroid conditions, including both Hashimoto’s and Grave’s disease. Non-autoimmune thyroid conditions such as cancer and hypothyroidism are also associated with the infection.
Why is this?
The stomach and the thyroid gland are related in the development of the human embryo during pregnancy. Also, a similarity between H. pylori and thyroid epitopes has been reported - epitopes are a specific part of antibody/antigen cells presented to the body for immune evaluation. The damage of gastric cells by H. pylori infection exposes epitopes to the immune system, thus potentially triggering an autoimmune response via molecular mimicry (“copy-catting”). However, while acute infection by H. pylori induces a strong proinflammatory immune process, the chronic, persistent infection induces instead a relatively weak type-2 immune reaction, driving the reprogramming of numerous immune cells and responses. This promotes the survival of H. pylori in the host and also results in an increased probability of immunotolerance impairment.
H. pylori and aluminum
Research shows that aluminum enhances inflammation and reduces healing capacity in the mucosal barrier. Aluminum is a widespread light metal in our environment and its influences are increasing as its presence and usage increases. Many current day industries use and/or spread large amounts of aluminum, and its presence in our air and water is on the rise. These include transportation, construction, and electrical manufacturing.
With both enhanced inflammatory responses and lowered barrier healing responses, the body is at risk for other diseases associated with leaky gut and lowered immunity. It is critical to assess aluminum (and heavy metal) burdens when investigating bacterial infections such as H. pylori. Again, at True Nature, we have effective ways of doing this and effective ways of working with toxicity and poor excretion patterns through our holistic telehealth services.
H. pylori Summations and Solutions
In summation, H. pylori is a complex pathogen capable of derailing proper nourishment and increasing other disease risks including GI cancers. It is acid-tolerant and highly contagious between humans sharing food and kissing. Gut health support requiring a comprehensive understanding and investigation of the body’s metabolic processes and needs is highly advised. Checks and cross-checks with influences and counter-influences are necessary. Some examples of this are:
Is the diet of the infected person appropriate for their needs? Are there sufficient foods to stimulate acid production? Is the liver being nourished by the individual’s diet?
Are there dietary and/or toxin stressors adding to pathogen hosting and/or poor gut membrane integrity?
Is the liver producing adequate enzymes for adrenal hormone production?
Are there signs or concerns of cardiovascular compromises or disease?
Are cholesterol and other steroid hormone levels normal and balanced? Are there excesses and imbalances that could be altering the cell membrane integrity? What is the source of the inflammation causing such imbalances?
What role is chronic stress playing in the expression of immune and detoxification processes in the body?
Are there adequate vitamin D levels in the body (both stored & active)? Are the VDRs functioning optimally?
Is oxidative stress under control?
Are there signs of tissue breakdown in the body? (muscle wasting, weight loss, low creatinine levels)
Is there an infected partner with whom the risk for personal infection is elevated?
H pylori is a gram negative bacteria that is becoming increasingly resistant to antibiotic treatment. Promising results have been recorded, however, in response to treatment with black seed oil. Treatments with 1 G of black seed oil daily provided eradication of the bacteria at 86% as well as improvement of dyspepsia symptoms.
Working with a practitioner who understands the roles of the hormones and glands in addition to the GI tract is important to recovery and long-term success. Please contact me at Julie@truenaturehealthconsulting for more information and/or investigation of your individual health. We provide holistic telehealth services.
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